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This spectrum extends from less severe forms of injury to more advanced injury when acute kidney failure may require renal replacement therapy (RRT).
Clinically AKI is characterised by a rapid reduction in kidney function resulting in a failure to maintain fluid, electrolyte and acid-base homoeostasis.
There have previously been many different definitions of AKI used in the literature which has made it difficult to determine the epidemiology and outcomes of AKI.
It is anticipated that this definition and staging system will be adopted globally.
This will enable future comparisons of the incidence, outcomes and efficacy of therapeutic interventions for AKI.